Carcinogenesis. 2010;1807: 620– 5. What she established was that low serum insulin up-regulates the sirtuin genes which in turn rev up the immune system and the cellular repair mechanism, and increase cellular apoptosis. Seyfried, Antiangiogenic and proapoptotic effects of dietary restriction on experimental mouse and human brain tumors. 2005;354: 140– 6. 100 years ago numerous doctors cured cancer, often routinely. Another commenter posted a comment from Prof. Seyfried on this paper…there do appear to be osme holes with the findings. Early detection (using AMAS or Nagalase) saves lives. But what they found instead was an almost random collection of mutations – not a single one, or any combination for that matter, being absolutely responsible for initiating the disease. Fun Facts about the name Cancer. Glioblastoma is an aggressive type of cancer that can occur in the brain or spinal cord—glioblastoma forms from cells called astrocytes that support nerve cells. That’s the reason we haven’t CURED CANCER because CANCER IS MANY DIFFERENT DISEASES that have certain properties in common. Trends Biochem Sci. 28. Dominic D’Agostino, active on this thread, is researching exactly that (hyperbaric therapy). Surgery was out of question because I have only one lung with cancer. The malignant and viral entities that make Nagalase are not normally present, so its appearance is a big deal from a diagnostic perspective. You said: ” The comment made by Mr Christofersson that cancer death rates haven’t changed since 1950 is completely incorrect.”, The point from the link I was referring to: “After all, despite a half-century of research by some of the best medical minds in the world, the death rate from cancer hasn’t changed much since the 1950s”. 44(1): p. 212-6; discussion 216. wanted me to have a biopsy. When was the first name Cancer first recorded in the United States? 4. This is a tremendously exciting concept Travis .. that potentially reducing sugar intake could starve cancer cells. If you think of them all like one disease you’re not going to think of them correctly. Throughout, I have struggled to keep in ketosis mostly due to my sweet-tooth but also due to intermittent worries about nutrient and fibre intake etc, but at the very least have been consistent in keeping my diet low carb except for about a week in July when I was persuaded to do ‘carbo-loading to strengthen myself’. I came across the article, What is The Origin of Cancer?. You will almost need to eliminate weight loss in order to eliminate or at best reduce the release of omega 6 PUFA if the patient has been living on soy oil or Flora for a lifetime…”. That dogma has been so hard to reverse even though we now know certain fats (most) ,are good and too many carbs are terrible) But dogma, one established, is THERE. Researchers would finally know cancer in its entirety – they would be staring the relentless shape-shifting enemy directly in the face, with nowhere for it to hide. See all Hide authors and affiliations. BMC Cancer 14(186): 1-8. Josh, Clifton Leafs new book “the truth in small doses” does a great job addressing those issues. He claims that the abnormal energy metabolism in cancerous tissue is not due to the neoplastic cells, but rather to the cells in the supporting stroma. It started when I met a very nice woman who claimed to have healed herself with it and even wrote a book about it, but the cancer returned about a year later. “MUST READ” for everyone & share with their friends & families, My recent blood test indicated that my PSA was elevated and my Urologist Nutr Metab (Lond), 2010. Knowing that genetics isn’t destiny urges us to seach for the factors we can control that determine disease expession. Metastasis involves aggressive and versatile cancer cells with the ability to degrade membranes, enter into the circulatory system, invade into new sites, change shape, and secrete growth factors and cytokines. I have been studying antique medical text for over 25 years now and know beyond any reason or doubt that cancer IS A METABOLIC DISORDER. If you are storing/burning mostly saturated and mono-unsaturated fats, it seems cancer doesn’t like that as much. 3. The metabolic theory of cancer contends that the disease begins with damage to the mitochondria thus impairing oxidative energy production — the cell is then forced to produce energy through fermentation in order to survive. We love having people like you who are open to new ideas. 2010;107:7117–7118. Now a critical eye must be cast on just how diluted this new, modified theory had become. Just picked is even better. Cancers are classified by the type of cell that the tumor cells resemble and is therefore presumed to be the origin of the tumor. Once damaged the mitochondria send out signals that activate a series of important oncogenic pathways, altering huge swaths of the genomic landscape, waking-up some genes, putting others to sleep, but when taken together, manifest in uncontrolled proliferation and genomic instability — the most salient features of cancer. Watson’s frustration this time was not an undertone but instead boiled over – declaring, “the ‘curing’ of many cancers seems now to many seasoned scientists an even more daunting objective than when the ‘War on cancer’ was started by President Nixon in December 1971.” The seemingly random nature of the mutations coming from the TCGA caught everybody by surprise. With over 2.8 million publications dedicated to understanding the obscure molecular mechanics operating within the cancer cell, cancer research lends itself well to a back-room detective approach – with papers scattered all over the floor and tacked to walls, scouring the evidence waiting for patterns and clues to emerge. Exp Cell Res. Wow what a great article! That people will actually take the time to read them…that’s another thing entirely. Designed by Pautler Design. Article; Info & Metrics; eLetters; PDF; This is a PDF-only article. Early on, once it was clear the data from the TCGA did not support the Somatic Mutation Theory of Cancer; Dr. Thomas Seyfried of Boston College didn’t wait around for the data to make sense like so many others. The history of cancer actually begins much earlier. It is all backed by references. The aggressiveness of the cancer also correlates to the degree of glucose consumption. Okamura S, Ng CC, Koyama K, Takei Y, Arakawa H, Monden M, Nakamura Y. Think: radiation has been around for over 100 years. National Cancer Institute http://www.cancer.gov/statistics This overview highlights some fairly significant milestones. By enabling earlier and therefore less invasive treatment options, this information provides a huge head-start. This is truly a masterpiece of medical journalism. Rho, The ketogenic diet as a treatment paradigm for diverse neurological disorders. Nevertheless, the government did not imprison Warburg, because it was believed Hitler was terrified of cancer, and Warburg was the world’s foremost expert at the time. http://www.dr-gonzalez.com/jco_rebuttal.htm. Maybe this is just how slow entrenched, dogmatic belief-systems are to change course. When it is cancer and the lives of millions are at stake the thought of trying to remain right when wrong costs lives; this is not a good image. Lorraine Day, Aajonus Vonderplanitz and others were healed after unwillingly water fasting. But that fleeting moment of optimism, I’m sure Watson would attest, was followed by decades of excruciatingly slow progress. 11. Blood. Biochim Biophys Acta. How would you like it if your neighbor moved his fence over into your backyard? After my week of carbo loading I had a return of bleeding, presumably from my bowel tumour, which stopped again once I got back into ketosis, and hasn’t returned to date. What if the reason progress has been so terribly elusive is not only because of the reasons Leaf has identified above, but also, and more importantly, because researchers have gotten the theory of cancer wrong? If cancer researchers have ever had a collective “stand-with-your-mouth-wide-open in shock” moment, it is right now. In “Cancer as a metabolic disease” dr. Seyfried mention at some point that the calorie restriction is more important that the type of diet. I’m not opposed to the ketogenic diet at all, just wondering because of the rest of the nutrients (enzimes and vitamins) than the body need (particularly if undergoing chemo) maybe better provided with a different type of diet. Turns out the blood-sugar lowering drug not only prevents cancer, but can also treat cancer – unequivocally suggesting a connection between metabolism and cancer. The cancer-research medical complex, with its massive infrastructure, all the investment, and livings derived from it – from the businessmen and salesmen, to the doctors and nurses, is as encompassing as a black-hole, and struggles to move with the inertia of an arctic glacier. History is replete with examples of humanity getting huge scientific issues dead-wrong for protracted periods of time – often with large institutions behind it –persecuting the intrepid few who first question the status quo. In the case of a family member with an elevated PSA, the biop confirmed that it was a false positive. The genetic theory of cancer, of course, proposes critical sequential-mutations will result in a less aggressive cancer acquiring all these metastatic features – random mutations that result in a tremendously complex gain of function. As I had said in my first point, you appear to be promoting a single author, a single website, and now, a book. By Otto Warburg. 24. You won’t read about this in the newspapers yet, about the confusing data coming out of the TCGA. doi: 10.1074/jbc.M705232200. I completely understand this is a controversial subject — but everyone I’ve interviewed or emailed for this article, including all those who don’t agree with the metabolic theory — have been open, willing to share, and perfectly pleasant. The authors of the pancreatic cancer study said this about the somatic mutation theory’s new paradigm shift, “From an intellectual viewpoint, the pathway perspective helps bring order and rudimentary understanding to a very complex disease.”. When you start screaming at me that you are being censored my “cookoo” alarm is triggered. The most important point, the crux of the entire issue, is that the mutations thought to be the decisive event, supersede metabolic dysfunction. Hu W, Zhang C, Wu R, Sun Y, Levine A, Feng Z. Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function. As you already know, GcMAF is a cell-signaling glycoprotein that talks to macrophages, enabling them to rapidly find, attack, and kill viruses and cancer cells. Unfortunately, his regenerating liver could not detoxify the administered antibiotics and he passed away. Good question though. 29. He suggests that tumor fibroblasts feed ketones and lactate to drive growth in the respiratory competent neoplastic cells. 2002;21: 53– 63. 70 – 80 million years ago Evidence of cancer cells in dinosaur fossils, found in 2003. Gautherie M, Gros CM. EMANUEL EEVICI, M.D. Also check out the website http://www.singlecausesinglecure.com and donate. While this phenomenon may occur in the genetically altered culture system used by the authors, there is no evidence that this occurs naturally in cancer cells in vitro or in tumors in vivo. Efficacy has been scientifically established, long term side effects have been dispelled, palatability has been dramatically enhanced, and difficultly of administration has been equally dramatically reduced. After 7 courses of Oxalyplatin chemo and 6 months of low carb diet my liver is now cancer free. It seems the group proposing it has some very profound holes in there research. Galaxies were rotating much faster than predicted by classic Newtonian mechanics – something else was at work here, something that could not be seen. regarding the origin of cancer in 1838 by way of arguing that blastemas were budding cells and not lymph. Cancers of the blood and lymph glands are called leukemias and lymphomas respectively. I am a breast cancer patient and chose hollistic treatment of cruciferous vegetables and specific diet, supplementation (to detox, build immunity, inhibit cancer cells, angiogensis, and growth, and strengthen overall health), exercise – and I will be changing to the Ketogenic diet for cancer management. “After screening only nine compounds we found one, called 3BP, that was incredibly powerful. When you look at cancer being Larmarkian evolution gone haywire a whole new world opens up, a mind boggling world where Darwinism becomes even more irrational than Creationism. doi: 10.1038/sj.emboj.7600461. Combining that with anti-glycolytic, and anti-glutamine pathway compounds and perhaps other supportive measures such as IV vitamin C, Alphalipoic acid and hyperbaric oxygen therapy give a patient a measure of hope and control over their own destiny that the current paradigm does not really provide in many cases. 5: p. 33. Article; Info & Metrics; eLetters; PDF; This is a PDF-only article. There is no known metabolic pathway by which fibroblasts can produce ketone bodies from glucose. We’ll probably never know whether or not, on some deeper level, DBP knows that Nagalase’s motives are dastardly—but it doesn’t really matter: DBP will definitely always obey. Thus they are genetic in nature by definition. Mitochondrial dysfunction leads to nuclear genome instability via an iron-sulfur cluster defect. There are so many inconsistencies to the somatic theory. Lu J, Sharma LK, Bai Y. 26. Whatever the case may be, billions are still being spent chasing down and cataloguing the mutations thought to cause cancer. The patient was a 16 year old with hepatocellular carcinoma (HCC), i.e., liver cancer. Before the recent advent of “deep-sequencing” technology, researchers have not been able to go very “deep” into intra-tumoral heterogeneity to always establish a clonal origin. Sarcomasare cancers of the supporting tissues of the body, such as bone, muscle and blood vessels. 45. Its formal, official chemical name is alpha-N-acetylgalactosaminidase, but this is such a tongue-twisting mouthful of a moniker that we usually just call it “Nagalase.” (Sometimes, when I want to impress friends with my brilliance, I’ll say the entire word real fast: “alpha-N-acetylgalactosaminidase.” I have found that it’s important to practice beforehand if one doesn’t want to embarrass oneself.). And if someone does come up with a cure that is not profitable or can’t be patented, they will be discredited quickly. He is all about wanting to see the references as to your qualifications to write on the subject. There are none. Nitrosamines No, it was implied when the commenter asked for credentials, you said he was a postdoc whose papers should be easy to find. WHY??? When calories are reduced to a certain threshold the body initiates a process called autophagy (self-digestion). If you mean I’m trying to promote the foundation website, I am. cancer definition: 1. a serious disease that is caused when cells in the body grow in a way that is uncontrolled and…. 2008;372:137–141. After class we walked down the atrium balcony to his lab. But that was not to be the case – maybe the decades of work teasing out oncogenes had been more thorough than researchers realized. It is that western medicine fails to seek the cause but to justify their proliferation of drugs doing nothing to stop the disease or prevent it wisely. Veech, R.L., The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism. 5(2). And Vogelstein offers one up in a section titled “dark matter.”. It can be inherited from parents or it can be acquired during life. Please, check out our website http://www.cancercuremedicine.com that contains information about 3-bromopyruvate, the only agent that can obliterate cancers and the only drug that can so far be THE CURE, the long-desired, ever-evasive and now possible cure for Cancer. Mostly because the data is still being collected, and right now the entire field of cancer biology is collectively in the middle of a hasty and massive reorganization. Specifically, the word “defiantly” is used repeatedly where the meaning clearly is “definitely”. EMBO J. Imagine- genetic mutations aren’t the CAUSE of cancer, merely a BYPRODUCT (albeit quite harmful) of underlying metabolic mitochondrial abnormalities. It is disturbing that NH&MRC grants could be funding such research and begs the question is this unwitting or not. Amazingly, the tumor shrank by 15% in the first 3 months! One of the earlier commenters remarked that there was a lack of evidence that keto diet was effective in fighting cancer but imo the lack of evidence is mainly due to a complete lack of interest in diet amongst the medical community( certainly in the UK where I live). i have downloaded it for free in PDF from Google and it is incredible reading. Not only that, the doctors take away their patient’s hope by limiting the length of time they have left to live and take no measures to support their patients in take responsibility for their own health. History provides the perspective to approach this question with – every generation thinks they are on the cutting-edge of modern technology – when in truth; our reference frame is just a blink-of-an-eye in the continuum of time. http://www.ncbi.nlm.nih.gov/pubmed/19687327, http://www.dr-gonzalez.com/jco_rebuttal.htm, http://articles.mercola.com/sites/articles/archive/2013/03/10/ketogenic-diet.aspx, Ketone body utilization drives tumor growth and metastasis, http://high-fat-nutrition.blogspot.cz/2013/08/starvation-and-cancer-growth-sauer-vs.html, http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0065522, http://www.amazon.com/Cancer-Metabolic-Disease-Management-Prevention/dp/0470584920, http://eatingacademy.com/nutrition/is-ketosis-dangerous, http://eatingacademy.com/nutrition/ketosis-advantaged-or-misunderstood-state-part-i, http://eatingacademy.com/nutrition/ketosis-advantaged-or-misunderstood-state-part-ii, http://www.biomedcentral.com/1471-2407/14/331, http://www.theepochtimes.com/n3/753288-a-new-understanding-of-the-cause-of-cancer/, https://www.karger.com/Article/FullText/362978, http://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-14-186, http://www.karger.com/Article/FullText/443106, http://clintransmed.springeropen.com/articles/10.1186/s40169-016-0093-6, http://www.drwhitaker.com/berberine-the-newest-most-powerful-discovery-for-fighting-diabetes, http://www.amazon.com/Alpha-Lipoic-Acid-Breakthrough-Antioxidant/dp/0761514570/, https://groups.yahoo.com/neo/groups/lowdosenaltrexone/info, http://www.amazon.com/Curing-Cancer-Carrots-Ann-Cameron-ebook/dp/B00JY2QG8K/, http://www.crossfit.com/cf-journal/seyfriedInterview.pdf, http://www.ncbi.nlm.nih.gov/pubmed/?term=glioblastoma+patient+with+a+double+nickle, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375045/figure/F5/, http://robbwolf.com/2013/09/19/origin-cancer/, http://www.medicalnewstoday.com/opinions/103745/, http://www.medicalnewstoday.com/opinions/122203/, http://healthland.time.com/2011/07/13/almost-every-type-of-cancer-kills-more-men-than-women-study-shows/, http://www.medicalnewstoday.com/opinions/177506, http://www.medicalnewstoday.com/opinions/177299, http://www.medicalnewstoday.com/opinions/177370, http://www.medicalnewstoday.com/opinions/177452, http://www.medicalnewstoday.com/opinions/171557, https://plus.google.com/107119198688120551734/posts, http://galacticconnection.com/father-oncology-vadim-shapoval-says-cell-needs-iron-overload-becomes-cancerous/, http://healthland.time.com/2013/04/01/the-conspiracy-to-end-cancer/, http://www.ovarian-cancer-facts.com/cancer-facts.html, http://www.ovarian-cancer-facts.com/what-is-cancer.html, https://www.youtube.com/watch?v=k2ETte7FQlM, http://www.youtube.com/watch?v=cCUGua_1dpg, https://foundationformetaboliccancertherapies.com. 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